AOR SAMe - Promotes Emotional Well Being - 400 mg 60 tabs

A Metabolic Key SAMe is a key factor in several biological events, particularly in methylation cycles. These cycles are one of the most common metabolic functions and drive many essential processes in the body. SAMe’s importance in the methylation cycle gives it roles in supporting joint health, mobility, normal liver function and mood. Look on the Bright Side of Life Methylation cycles in the central nervous system affect factors that are directly related to depression. SAMe affects the metabolism of B vitamins and neurotransmitters such as serotonin and dopamine, which are important in averting depression. SAMe’s effects on depression are so powerful that it is a legally registered prescription drug in several European countries. Help for Bones and Liver Clinical trials have found SAMe to be effective in relieving symptoms and reducing functional impairment in osteoarthritis. SAMe promotes liver health by protecting the liver from various toxins, and it acts as an anti- oxidant and anti-inflammatory agent. These important benefits make SAMe a good choice for maintaining and enjoying good health. S-Adenosyl-l-methiononine, or SAMe, is a naturally-occurring physiological agent in the human body that forms an integral part of the methylation cycle. This compound is a prescription drug in much of Europe, most commonly as an anti-depressant. SAMe is safe, energizing, and purported to treat depression twice as fast as standard anti-depressants such as ProzacTM. SAMe is also heavily studied for its ability to alleviate the conditions of osteoarthritis as well as to treat liver disease. The Methylation Cycle Methylation is one of the most common metabolic functions of the body, occurring on the order of a billion times per second. The methylation cycle affects everything from central nervous system activity to cholestasis in pregnancy. As the body ages, the outer lipids of the cells harden, but methylation keeps that layer supple. For this reason, it is theorized that in order to help overcome the process of cellular aging, the body needs a constant and steady supply of methyl donors, of which SAMe is among the most prolific. It must be noted that it is critical to maintain adequate vitamin B supplies as they seem to work synergistically with SAMe. SAMe and Depression It is as an anti-depressant that SAMe seems to have established itself in the collective mindset of the scientific community. The influence of the methylation cycle is so widespread that it affects factors of the central nervous system that are directly pertinent to depression. To begin with, methionine requires one-carbon groups to begin the methylation cycle. These one-carbon groups rely heavily on the B-complex vitamins for their amalgamation by methionine for the methylation cycle and the subsequent conversion to SAMe. The fact that inadequate concentrations of these vitamins are synonymous with depression have led researchers to theorize that supplemental SAMe enhances the metabolism of the B family of vitamins (especially folic acid), thus explaining the anti-depressant power within SAMe’s range of benefits. Another possible (and perhaps concurrent) explanation of SAMe’s anti-depressant properties is its effect on neurotransmitters in the brain, especially serotonin and dopamine. Serotonin is formed from tryptophan and has an important effect on learning, sleep, and the regulation of mood. The latter’s connection to depression is quite palpable, and SAMe is widely known to raise serotonin levels in the brain, providing another possibly accumulative avenue for the speed and effectiveness of its anti-depressant activity. Dopamine is another neurotransmitter that likely plays an even bigger role in the averting of depression than serotonin. Low concentrations of dopamine are not only affiliated with the conditions of depression (as are lower concentrations of serotonin) but they are also closely associated with Parkinson’s disease as well. SAMe’s effect on depression may also be linked to the hormone melatonin. Melatonin is derived from serotonin and plays an important role in sleep and by extension the aging process. Like the neurotransmitters serotonin and dopamine, low levels of melatonin are a frequently consistent observation in people suffering from depression. SAMe’s effectiveness as an anti-depressant has been demonstrated in many clinical trials. Other Benefits SAMe has also been found to be helpful in dealing with osteoarthritis. It appears to possess therapeutic effects similar to those of the standard non-steroidal anti-inflammatory agents (NSAIDs) used to treat osteoarthritis, but is better tolerated. SAMe is also beneficial for the health of the liver, likely due to its ability to increase concentrations of the antioxidant glutathione in hepatic tissue as well as in red blood cells in general. • An effective anti-depressant • Relieves symptoms of osteoarthritis • Supports normal liver function