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AOR GLA-240 - A Beneficial Fatty Acid - 90 Softgels

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Quick Overview

A beneficial fatty acid
• Anti-inflammatory
• Relieves pressure in joints and blood vessels
• Relieves symptoms of premenstrual syndrome
• Reduces symptoms of rheumatoid arthritis

AOR GLA-240 - A Beneficial Fatty Acid

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A beneficial fatty acid
• Anti-inflammatory
• Relieves pressure in joints and blood vessels
• Relieves symptoms of premenstrual syndrome
• Reduces symptoms of rheumatoid arthritis

Balanced signals
is gamma linolenic acid, an essential omega-6 fatty acid found in certain plant oils. GLA is a precursor for prostaglandin-1, an important cellular signaling molecule with a number of beneficial effects. GLA's ability to modulate the balance of cellular signaling molecules is useful in many ways. It reduces excessive inflammation, relieves pressure in joints and blood vessels, and reduces allergic responses.

Benefits for many conditions
Unbalanced eicosanoids are involved in many symptoms of menopause and premenstrual syndrome. Clinical trials have found that GLA supplementation alleviates symptoms of PMS, particularly depression. It is also effective for mastalgia. Studies using GLA have found improvements in patients with diabetic neuropathy. Clinical trials have also found that GLA can reduce the signs and symptoms of disease activity in patients with rheumatoid arthritis, and can help alleviate symptoms of atopic dermatitis.

A multitasking fatty acid
effects are beneficial in a wide variety of health conditions. AOR's GLA-240 is an extract from the seed pods of borage. It is a safe and well¬tolerated supplement that helps regulate inflammation and reduce the symptoms of a number of disorders.

Borage is a plant with star shaped, periwinkle-blue flowers. The plant produces a dark, rich oil that contains valuable therapeutic lipids. The seed pod usually contains about 25% oil content.

The body is capable of naturally producing GLA. In order to do this, it must have its starting material, linoleic acid (LA). This is an essential fatty acid that the body is unable to make and must be ingested as part of the everyday diet. Fortunately, most people get plenty of LA in their daily diet, since it is commonly found in almost all edible vegetable oils.

Once LA is ingested, it is acted upon by an enzyme called delta-6-desaturase (D6D) which biochemically converts LA to GLA. This is how the body gets its daily fix of GLA.

Without the effective functioning of D6D, the body is unable to manufacture any GLA no matter how much LA is ingested. GLA is further converted via a sequence of biochemical steps into prostaglandin 1 (PGE1), a key molecule with numerous biological properties including:

• Anti-inflammatory.
• Dermatology (e.g. eczema).
• Anti-allergy.
• Nerve transmission.
• Secretion from the mucus membrane.
• PMS.
• Steroid production and hormone synthesis.

The first vegetable source of GLA was discovered in the oil of evening primrose seeds (where GLA content is 9%). This oil became well known with the public, health professionals, and in health stores. Then GLA was also discovered in borage and black current in higher amounts, 24% and 17% respectively. A 1992 study published in the journal 'Lipids' showed that "there was no significant difference in tissue GLA levels within groups given equal amounts of dietary GLA either in borage oil or evening primrose oil". In order to ingest 240mg of GLA, only 1 000mg of 24% borage oil needs to be taken compared to 2 660mg of EPO. Because reduced consumption of oil is desirable as a rule, the higher GLA potency of borage oil makes it preferable to evening primrose oil.

Clinical Studies

1) Anti-inflammatory.
In rheumatoid arthritis (RA), benefit from non-steroidal anti-inflammatory drugs (NSAIDs) is mediated through inhibition of the cyclo-oxygenase enzyme, thereby decreasing production of the 2 series prostaglandins (PG2). The Lipoxygenase enzyme is intact, however, allowing leukotriene (LT) production; e.g. LTB4 is an inflammatory mediator. Treatment with GLA-240 leads to the production of the prostaglandin 1 series PGE1, which has less inflammatory effects. In addition, LT production is inhibited.

2) Post-viral fatigue syndrome. 63 adult patients were treated with GLA for 3 months in a double-blind, placebo¬controlled study. All patients had been ill for 1-3 years of a viral infection and were suffering from myalgia, severe fatigue and a variety of psychiatric symptoms. The essential fatty acid composition of the red cell membrane phospholipids improved significantly.

3) Mastalgia. 414 patients with mastalgia were treated with Danazol, bromocriptine, or GLA. Danazol was the most effective, with GLA and bromocriptine having equivalent efficacy. However, many more adverse effects were noted with danazol and bromocriptine.

4) Diabetic neuropathy. A 1 year study observed 111 patients with mild diabetic neuropathy who were treated with 480mg of GLA per day and assessed for 16 parameters including tendon reflexes, muscle strength, hot and cold sensation etc. For all parameters, the changes were more favorable and statistically significant in the GLA group. The conclusion was that GLA had beneficial effects on the course of diabetic neuropathy.

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Additional Information

ProductSKU 624917070033
Ingredients Contains: 90 Softgels
Serving Size: 1 Softgel

Amount per Serving:

Gamma linolenic acid (GLA) (from 100% borage oil) 240 mg
Vitamin E (D-Alpha tocopherol) 5 IU

Other ingredients:

ascorbyl palmitate. Softgel: gelatin and water.

AOR guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish or shellfish.

Suggested Use: Take one softgel daily with a fat-containing meal, or as directed by a qualified health consultant.

GLA is important for regulation of an array of bodily functions. Some of those functions are:

• Inflammation, swelling and pain.
• Pressure in joints, blood vessels.
• Water retention.
• Allergic response.
• Rheumatoid arthritis.
• Nerve transmission.
• Pre-menstrual syndrome.
• Obesity.
• Vascular disorders.
• Eczema.

Source: Seeds

Pregnancy / Nursing: Safe

• Possible interactions with phenothiazines (increasing seizure risk).
• May cause headaches and/or nausea.
• May increase bleeding time.

Other Ingredients .
Directions .
Warning .

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