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AOR I3C 200 - Promotes Safe Estrogen Metabolism - 200 mg 60 Vcaps

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Quick Overview

Promotes Safe Estrogen Metabolism
• Reduces the risk of women’s cancers
• Helps destroy breast cancer cells
• Reduces the formation of dangerous estrogens
• Promotes the formation of protective estrogens

AOR I3C 200 - Promotes Safe Estrogen Metabolism

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Promotes Safe Estrogen Metabolism
• Reduces the risk of women’s cancers
• Helps destroy breast cancer cells
• Reduces the formation of dangerous estrogens
• Promotes the formation of protective estrogens

Healthy Estrogen Balance
I3C is indole-3-carbinol,
a nutrient that is present in cruciferous vegetables such as broccoli and Brussels sprouts. I3C is a cancer-fighting nutrient, and supports a healthy balance of estrogen metabolism. There are two forms of estrogen metabolites: the “bad” estrogens which promote the development of breast cancer, and the “good” estrogens which are harmless or even protective against cancer formation. I3C reduces the formation of the former while increasing production of the latter.

Cancer-fighting Actions
I3C
can stop the growth of, or even destroy existing breast cancer cells. It blocks the activation of genes that contribute to cancer cell growth while activating genes that help to fight cancer. In studies, I3C has been found to reverse localized cancer of the cervix in women.

I3C or DIM?
I3C
is one of the most effective cancer-fighting compounds in cruciferous vegetables. Some studies suggest that DIM, a condensation product of I3C is also effective, however most clinical trials have used I3C. I3C has been shown to be effective in both cellular studies and human trials, and provides an extra weapon in the fight against women’s cancers.

Indole-3-carbinol (I3C) is a phytonutrient found in Brassica vegetables, which are known to help reduce the risk of many different kinds of cancer. In the last decade, evidence has been accumulating to suggest that I3C is one of the key active cancer-fighting ingredients in these foods.

The key risk factor in the development of most women's reproductive cancers is exposure to estrogen. "Estrogen" is not just one substance, but a family of hormones. Some estrogen metabolites are "bad" estrogens which can powerfully promote the development of breast cancer. On the other hand, "good" estrogens are either harmless, or may actually be protective against women's cancers.

Enter I3C
Several human studies have found that by shifting the balance of metabolic enzymes that process estrogens in the body, I3C reduces the formation of "bad" estrogens and increases the formation of "good" ones.

A prospective, randomized, double-blind, placebo-controlled trial tested I3C in women with localized cancer ("carcinoma in situ"). Thirty women with carcinoma in situ of the cervix (CIN) were given varying doses of I3C or a dummy pill for 12 weeks. The women's estrogen ratios were tested to see what effect the I3C would have on their estrogen metabolism. The study found a dose-dependent increase in the ratio of "good" to bad" estrogens in the I3C groups. More importantly, there was also a dose-dependent regression in degree of CIN. Astoundingly, carcinoma in situ had completely vanished in 47% of the women on I3C.

Breast Cancer
Only about 5% of breast cancer is caused by inherited genetic mutations. Most breast cells become cancerous in response to the things to which they are exposed. "Good" and "bad" estrogens appear to be key players in this process.

In animal studies, I3C has been repeatedly shown to prevent the development of breast cancer. I3C has also been found to prevent the appearance of the abnormal growths that lead up to breast cancer, and of early biochemical markers of its development.

Other Mechanisms
There's more to I3C's breast cancer prevention powers than its effects on estrogen metabolism. I3C also directly stops cancerous breast cells from multiplying by influencing gene expression. I3C increases the expression of cancer-fighting genes like the tumor-suppressing gene p53. At the same time, I3C stops the expression of a gene that promotes cell proliferation. It also increases the expression of BRCA1, a gene which is absolutely vital in the prevention of breast cancer.

I3C vs DIM
Recently, there has been some controversy about the relative advantages of I3C compared with one of its condensation products, DIM (diindolylmethane). While Studies have been conducted with DIM, much more evidence exists for I3C. We have a better understanding of I3C, and its effects on the body, than we do of DIM, and, in fact, much of the research being cited to support the use of DIM is actually research performed using I3C. Furthermore, animal studies have shown completely opposite effects on cancer when DIM is given at different doses: at one dose, it will prevent cancer, while at another dose, it will promote it.

Years of detailed analysis of the role of estrogen metabolites in women's reproductive cancers, extensive animal experiments, and now a successful controlled trial in human women all provide support for I3C’s ability to provide an effective natural support for safer estrogen metabolism, and thus for women's health.

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Additional Information

ProductSKU 624917080018
Ingredients Contains: 60 Vegi-Caps
SERVING SIZE: 1 Capsule

Amount per Serving:

Indole-3-Carbinol (I3C) 200 mg


Non-Medicinal ingredients:

microcrystalline cellulose. Capsule: hypromellose, sorbitol, silicon dioxide, water.


NOTE: I-3-C can have a strong, characteristic smell that may be unpleasant to some people.

AOR guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish or shellfish.

Suggested Use: Take one capsule twice a day. Do not take I•3•C 200 at the same time as antacids, H2-receptor blockers (eg. Zantac®), or proton-pump inhibitors (eg. Nexium®), as these drugs may impede the conversion of I3C to some active metabolites. Or as directed by a qualified health consultant.

Main Applications
• Safer estrogen metabolism.
• Risk reduction for women's cancers.
• Respiratory Papillomatosis (RP)

Source: Synthesis from indole.

Pregnancy / Nursing: No studies have been conducted. Best to avoid.

Other Ingredients .
Directions .
Warning .

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