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AOR Niacin No-Flush - A B Vitamin For Heart Health - 500 Mg 90 Vcaps

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Quick Overview

A B vitamin for heart health
• Supports healthy cholesterol balance
• Reduces the risk of heart attacks and strokes
• Lowers formation of blood clots
• Needed to synthesize energy¬production metabolites

AOR Niacin No-Flush - A B Vitamin For Heart Health

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A B vitamin for heart health
• Supports healthy cholesterol balance
• Reduces the risk of heart attacks and strokes
• Lowers formation of blood clots
• Needed to synthesize energy¬production metabolites

A good cholesterol balance
Niacin is vitamin B3, a precursor of the coenzymes NAD and NADP which are required in many essential biological pathways including energy production and DNA repair. Niacin is well known to support healthy cholesterol balance. It raises levels of "good" HDL cholesterol while lowering triglycerides, and it changes the composition of "bad" LDL cholesterol to make it less likely to contribute to atherosclerosis. Studies have shown that niacin reduces the incidence of heart attacks and stroke, and lowers their death rates.

The downsides of regular niacin
Regular niacin, while extremely beneficial for heart health, is associated with unpleasant effects. It can cause blood vessels to expand and release molecules that cause the skin to warm and itch in a symptom known as "flushing". Sustained release niacin avoids the flushing effect, but comes with the even worse side effect of potential liver damage.

A better solution
Inositol hexanicotinate is a form of niacin that is bound to inositol. This formation allows it to deliver niacin to the bloodstream slowly and in a controlled fashion, avoiding both the unpleasantness of flushing and the danger of liver damage.

Niacin (nicotinic acid, a form of vitamin B3) is an important cellular mediator. Niacin is metabolized primarily in the liver to niacinamide, which is a precursor to the two cellular coenzymes nicotine-adenine dinucleotide (NAD+/NADH) and nicotine-adenine dinucleotide phosphate (NADP). These coenzymes are responsible for carrying out numerous reactions in the body, including their role in energy production, and play a vital role in protecting and repairing DNA.

Different Forms of Niacin
The big problem with high-dose niacin supplementation is the niacin flush, in which blood vessels expand and release histamines (the immune factors responsible for some of the symptoms of allergies), thereby causing warming and itching of the skin. Early attempts to solve this problem with a simple "sustained-release" niacin formulation called niacinamide eliminated the 'flush,' but caused a much more serious one: sustained¬release niacin causes liver toxicity in a significant percentage of those taking it. Inositol Hexanicotinate (IHN - also sometimes called inositol hexaniacinate) is the true "flushless niacin." IHN is a niacin complex, formed with the B-vitamin-like inositol. When you take an IHN supplement, the central inositol ring gradually releases niacin molecules, one at a time - delivering true niacin, but in a controlled fashion governed by the kinetics of the hydrolysis of the molecule itself. No clinical trial has ever reported liver toxicity in persons supplementing with "flush-free" niacin.

Cholesterol … And Beyond
Niacin is the classic orthomolecule for supporting healthy cholesterol balance. Its greatest strengths are its powerful effects on boosting High-Density Lipoprotein (HDL, or "good" cholesterol) and in lowering triglycerides (TG). A recent study found that the ratio of TG to HDL ratio is perhaps the most potent predictor of heart attacks we know. Niacin also reduces levels of lipoprotein(a) (Lp[a]), a little-known, but especially deadly lipoprotein. Niacin also changes the biochemical composition of cholesterol in heart-healthy directions. The LDL "bad" cholesterol is much more likely to form atherosclerotic plaques when it's been oxidized (damaged by free radicals). Niacin converts the dense, easily-oxidized LDL particles to larger, more oxidation-proof ones, and it boosts the cholesterol-clearing powers of HDL. Independently of its effects on cholesterol, niacin also lowers fibrinogen. Fibrinogen is a necessary part of the normal blood clotting process but at elevated levels it can increase your odds of forming dangerous blood clots, which can plug off a blood vessel leading into your heart, triggering a heart attack. Fibrinogen also causes smooth muscle cells to proliferate, which can promote atherosclerosis.

The Real Endpoint
Niacin is the only true dietary supplement clearly proven to reduce heart attacks, strokes, and actual death rates. In one trial, niacin therapy cut the rate of nonfatal heart attacks by 27% and stroke by 26%. Men taking niacin supplements were 11% less likely to die from any cause compared to the placebo group. The reduction in risk was especially great in people who had the highest cholesterol levels to begin with. Niacin's ability to reduce the risk of heart disease, heart attacks and strokes has been supported by several other studies as well, and it can be combined with statin drugs to improve the safety and overall effects of both.

Peripheral Vascular Disease (PVD)
In addition to its ability to keep your arteries clean, IHN has been shown to be a highly effective therapy in the treatment of peripheral vascular diseases, including Raynaud's syndrome and intermittent claudication. IHN increases blood flow and raises temperature in the hands and feet, while allowing necrotic areas to heal. Given its safety, its orthomolecular status, its remarkable range of cholesterol-balancing effects, and its proven track record in slashing death rates, IHN may be the best first choice for most people with concerns about their cholesterol balance.

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Additional Information

ProductSKU 624917010138
Ingredients Contains: 90 Vegi-Caps
Serving Size: 1 Capsule

Amount per Serving:

Niacin (as inositol hexanicotinate 550mg) 500 mg


Other ingredients:

magnesium stearate. May contain < 0.2% Povidone K-30 USP24 or precipitated silica. Capsule: hypromellose, sorbitol, silicon dioxide, water.


AOR guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish or shellfish.

Suggested Use: Take one to eight capsules daily, or as directed by a qualified health care practitioner.

Main Applications
• Healthy Lipoprotein Balance
• Circulation
• Skin Health

Source: Pharmaceutical Synthesis

Pregnancy / Nursing: No studies; best to avoid

Cautions:
• While there are no reports of liver toxicity associated with inositol hexanicotinate, it is recommended that regular liver enzyme tests be done in consultation with a physician. Check with your health care professional immediately if any of the following side effects occur: darkening of urine; light gray-colored stools; loss of appetite; severe stomach pain; yellow eyes or skin. Do not take any form of niacin if you have existing liver disease.

• Likewise, while no trials have reported the following issues with inositol hexanicotinate, they have been reported in trials with conventional niacin supplementation and the following cautions must also apply: • Niacin may exacerbate peptic/duodenal ulcer, gout, or arterial bleeding. Consult your physician.

• Infrequent side effects of conventional niacin, seen in < 5% of high-dose users, include unusually fast, slow, or irregular heartbeat; difficulty urinating or unusually large volume of urine; loss of appetite; and unexpected weight loss.

• Some people taking niacin experience nasal inflammation, shortness of breath, or unusual thirst, sweating, tiredness, or weakness.

• Niacin may lower blood pressure. When combined with blood-pressure lowering drugs, this may lead to postural hypotension (lightheadedness or dizziness upon standing up suddenly).

• A small number of people have reported blurring or darkening of vision related to use of conventional niacin, caused by a swelling of the macula of the eye. These symptoms resolve themselves after one month of discontinued use.

• It was once believed that niacin would raise blood glucose levels in diabetics; however, this result was based on chance observations and short-term studies. Several long-term trials have now shown that niacin is safe for diabetics.

• Niacin may alter laboratory tests of thyroid hormones; however, the clinical significance of these changes, are not clear.

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