Complete, balanced vitamin E supplementation

Vitamin E plays as a team.
Vitamin E is not just one vitamin, but is made up of a complex of 8 distinct molecules (four tocopherols and four tocotrienols), all of which have unique functions.

Everyone has a role
Tocotrienols reduce cholesterol synthesis and are powerful antioxidants. Gamma tocopherol detoxifies free radicals that could contribute to Alzheimer's disease, suppresses inflammation and may reduce the risk of prostate cancer. Other vitamin E molecules lower cholesterol and blood- pressure. As an extra boost, coenzyme Q10 is included to recharge vitamin E molecules when they are deactivated by oxidants.

Don't lose your balance
Vitamin E supplements often put the focus on alpha-tocopherol. However, alpha-tocopherol alone lacks the abilities of the other members of the complex. Both tocopherols and tocotrienols are important for health. Unbalanced alpha-tocopherol supplementation has even been shown to deplete the body of other E molecules, negating many of their benefits! AOR's Total E is the first balanced and complete E-complex supplement, ensuring that you don't lose out on any of the health benefits provided by the full E team.

Vitamin E is often though of as one molecule: alpha-tocopherol. But vitamin E is a complex, like the B-complex. The E complex is an eight-member family, composed of eight closely related vitamin E molecules (or "vitamers"): four tocopherols and four tocotrienols. Each member of the vitamin E complex has its own unique strengths and properties not shared with other E vitamers. Studies show that unbalanced alpha-tocopherol supplementation actually depletes the body of the other members of the family, and can negate many of their benefits!

Tocotrienols
The tocotrienols' unique chemical structures allow them to move around more freely in cell membranes. As a result, the tocotrienols are forty to sixty times more potent antioxidants than the tocopherols in biological membranes.
One of the key benefits of the tocotrienols is their ability to reduce cholesterol synthesis by reducing the activity of a key enzyme in this process. Clinical trials have shown that a high-dose tocotrienol complex can help restore cholesterol balance in people whose levels are too high.

Extracellular fluid pressure plays a key role in the regulation of blood pressure, and high extracellular fluid pressure puts you at risk of congestive heart failure, cardiac fibrosis, and liver cirrhosis. It was recently found that gamma-tocopherol and gamma-tocotrienol, but not alpha-tocopherol, help control extracellular fluid pressure.

A key step in the development of atherosclerosis is the invasion of injured blood vessel walls by certain types of immune cells. A recent study found that alpha-tocotrienol prevented these cells from sticking to the vessel walls. Alpha-tocotrienol has also been found to have protective effects on brain cells.

Gamma-tocopherol
While low-dose alpha-tocopherol appears to reduce the risk of prostate cancer, high-dose alpha-tocopherol may actually increase prostate cancer risk. This may be due to alpha-tocopherol's ability to deplete gamma-tocopherol. High blood levels of gamma-tocopherol have been associated with a decreased risk of prostate cancer.
Alpha-tocopherol is a good antioxidant against many kinds of free radicals, but gamma-tocopherol is much more effective in detoxifying nitrogen-based free radicals, which appear to be especially virulent in the brains of people with Alzheimer's disease. Victims of Alzheimer's disease were found to have a specific depletion of gamma-tocopherol in areas of the brain affected by the disease. Gamma-, but not alpha-tocopherol can also significantly protect the enzyme alpha-ketoglutarate dehydrogenase from nitrogen-based free radical damage. Levels of this enzyme have been found to be significantly reduced in the brains of people with Alzheimer's.

Low plasma levels of gamma-tocopherol - but not alpha tocopherol - are found in patients with atherosclerosis. These patients often have an unbalanced ratio of alpha- to gamma-tocopherol. Crucially, most of the vitamin E in the food we eat is gamma-tocopherol, while most "vitamin E" supplements are overbalanced with alpha.

Other Tocopherols
In vitro studies have found that delta-tocopherol, as well as all four tocotrienols, but not alpha-tocopherol, have the ability to destroy breast cancer cells.

Total Protection
Total E is the first complete, full-spectrum, balanced E complex supplement in Canada, providing alpha-, beta-, gamma- , and delta- tocopherols and -tocotrienols in a potency designed to create an excellent E complex profile. The formula also includes Coenzyme Q10, because this nutrient plays a vital role in "recharging" E vitamins to their active antioxidant form when they are deactivated in the battle against free radicals.
Vitamin E is a team, not just a goalie: eight molecules, not one. Make sure your team is complete.

• Contains all 8 vitamin E molecules
• Fights oxidants
• Suppresses inflammation
• Reduces the risk of heart failure