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Now SAMe - 200 mg 60 tablets

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Quick Overview

• treatment for depression
• improves serotonin and dopamine levels
• relief from arthritis pain

Now SAMe 200 mg 60 tablets

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Though discovered in 1952, the past six years have crowned SAMe as one of the most widely used supplements in todays marketplace. As a natural line of support to the nervous system functions, it increases the synthesis and breakdown of certain neurotransmitters, thus enhancing the sensitivity of nerve receptors. It may also aid in the repair of myelin, the sheath of fatty material that surrounds the nerve cells. SAMe may support joint health through transulfuration, a process that takes a certain amount of sulfur from SAMe to create glucosamine and chondroitin sulfates. This enhances proteoglycan synthesis, the molecule responsible for keeping articular joint cartilage lubricated. Important for the production of glutathione, this powerful free radical scavenger defends the body from toxic agents and is necessary for liver detoxification.

Preliminary research suggests that SAMe is more effective than placebo in treating mild to moderate depression and is just as effective as anti-depressant medications without the side affects frequently associated with the medications (headaches, sleeplessness and sexual dysfunction). Plus, antidepressants tend to take six to eight weeks to begin working, while SAMe seems to begin much more quickly than that.

More research regarding the safety and effectiveness of SAMe, especially for longer periods of time, is needed. It is not clear exactly how SAMe works to relieve depression, so it is best to avoid using SAMe together with other antidepressants. In addition, given the serious nature of this mood disorder, professional help should be sought for symptoms of depression before taking SAMe or any substance.

Laboratory and animal studies suggest that SAMe may reduce pain and inflammation in the joints as well as promote cartilage repair, but researchers are not clear about how or why this works. Clinical trials with people (although generally small in size and of short duration) have also shown favorable results for SAMe when used to relieve osteoarthritis symptoms. In several short-term studies (ranging from 4 to 12 weeks), SAMe supplements were as effective as NSAIDs (nonsteroidal anti-inflammatory drugs) in adults with knee, hip, or spine osteoarthritis. SAMe was equivalent to the medications in diminishing morning stiffness, decreasing pain, reducing swelling, improving range of motion, and increasing walking pace. Several of the studies also suggest that SAMe has fewer side effects than NSAIDs.

From studies comparing SAMe to placebo, this supplement seems to improve pain, fatigue, morning stiffness, and mood in those with fibromyalgia.

Liver Disease
Results of several animal studies suggest that SAMe may be beneficial in treating various liver disorders, particularly liver damage caused by excessive alcohol consumption. Animal studies also suggest that SAMe may protect the liver from damage after acetaminophen overdose (a pain-relieving medication purchased without a prescription). A study of 123 men and women with alcoholic liver cirrhosis (liver failure) found that SAMe treatment for 2 years may improve survival rates and delay the need for liver transplants more effectively than placebo. Although the results of this study are encouraging, more clinical trials are needed to determine whether SAMe is safe and effective for the prevention and/or treatment of liver disease.

Alzheimer's Disease
Studies suggest that people with Alzheimer's disease (AD) have low levels of SAMe in the brain and that supplementation can actually increase those levels. While it has been reported that some individuals with AD have improved cognitive function from SAMe supplementation, well-designed research studies are needed to determine whether this supplement is truly safe and effective for people with the disease.

Although it is premature to tell if these are safe or appropriate uses for SAMe, some early research has looked at the relationship between SAMe and Parkinson's disease, migraine headaches, Sjogrens disorder (which causes pain in connective tissue), attention deficit/hyperactivity disorder (ADHD) in adults, and vascular disorders such as heart disease.

SAMe levels may be low in people with Parkinson's and heart disease. However, experiments in rats have indicated that SAMe supplements may actually cause Parkinson's disease in these animals.

Given SAMe's structure, some have raised concern about the potential for SAMe to increase homocysteine levels. (Homocysteine has been shown to contribute to the development of plaques in the blood vessels). However, early information suggests that SAMe may actually lower homocysteine. Research is needed to know whether taking SAMe supplements may reduce homocysteine and reduce one's chances of getting heart disease.

A preliminary study of 124 migraine sufferers suggests that SAMe may decrease the frequency, intensity, and duration of headaches as well as lead to an improved sense of well being and use of fewer pain killers.

• treatment for depression
• improves serotonin and dopamine levels
• relief from arthritis pain
  1. SAMe Review
    4 5

    Sam-e supplements are often used to treat depression, as an alternative to prescription anti-depressants like Prozac. Sam-e is naturally produced when amino acid L-methionine combines with ATP in the body. The highest concentrations of Sam-e are in the brain and liver.

    Sam-e helps regulate serotonin levels in the brain. Since, depression is often caused by unbalanced serotonin levels, Sam-e helps treat depression. St. John’s Wart works similarly, although many consider Sam-e to produce quicker results.

    Sam-e is not only used for treating depression, but also arthritis and liver disease. There are some studies that back up these claims including a study that found it useful in treating knee osteoarthritis symptoms. Studies have also found effective at treating major depression.

    While Sam-e is not regulated in the US, it is still best to check with your doctor before using, as it is a synthetic version of a chemical and thus a drug and not a natural or dietary supplement.

    There are some reported negative side effects related to using Sam-e including headaches, upset stomach, short term memory loss, and dizziness. It is not recommended for those with bipolar disorder, as it can bring on or worsen manic episodes. Additionally, it should be used on its own and not along with other anti-depressants.

    It seems at least worth trying for those suffering from joint pain. It also appears effective at being an antidepressant, although further research needs to be carried out, especially related to long-term safety and effectiveness.

  2. No bad side effects
    5 5

    I've been taking SAMe for a long while in 100mg/day doses. As far as I can tell the effect has been positive even with a small amount, although I'm aware advice may be different as to dosage. I also take vitamin B12 along with other B vitamins, which may have alleviated side effects, but I haven't experienced anything bad in taking SAMe. There is advice not to take this if you have bipolar disorder, and I have found that if I take too much it can make me a bit hyper (although I haven't been diagnosed with bipolar disorder) - so I would say take a small dose daily first to see if there are any problems and then slightly raise the dose depending on other advice. I also take SAMe with a small amount of food - usually yoghurt, which again I think isn't advised, but I do this to avoid any stomach problems. Again, probably best to try without food - as advice is that it is taken up in the body more effectively, and then if there's any problem, change what you do as appropriate. Astronutrition have always been very good at delivering the product, and I've been pleasantly surprised at the short length of time it takes to ship the product from Canada to the UK - it can sometimes take less time - a week to 10 days - than products I order in the UK.

  3. Miraculous! I've been taking these for 3weeks now and I am very pleased with the results! I've experienced more positive feelin...
    5 5

    I've been taking these for 3weeks now and I am very pleased with the results! I've experienced more positive feelings of happiness and I've been able to handle things in a less stressful manner. I have more energy and have been able to exercise more often without feeling so tired. I also sleep much better and feel more rested. The only downside is the mild headaches the first week, which have now disappeared, vitamine B12 helps with that. I seems to be working wonders for me, but it's only been 3 weeks, but so far so good!

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Additional Information

ProductSKU 733739001382
Manufacturer Now
Per Container: 60
Form tablets
Serving Size 1 Tab
Ingredients Vitamin B-6 2mg 100,Folic Acid 200mcg 50,Vitamin B-12 50mcg 833,SAMe (S-Adenosyl-L-Methionine) 200mg
Other Ingredients .
Directions As a dietary supplement, take 1 tablet daily, preferably on an empty stomach. Refrigeration is recommended after opening.
Warning Individuals with bipolar (manic) depression should not take SAMe unless under professional medical supervision.

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